Motivational control is implemented by a cingulo-prefrontal pathway

• DOI: 10.1101/2025.02.11.637635
• Publication Date: 2025-02-12T12:15:16Z
• Authors: Clémence Gandaux; Jérôme Sallet; Céline Amiez; Delphine Autran-C...; Valentine Morel-L...; Clément Goussi-De...; Vincent Fontanier; Pierre Misery; Camille Lamy; Frank Lamberton; Marina Lavigne; Eric J. Kremer; Charles.R. E. Wilson; Emmanuel Procyk

Abstract The neuronal connections between the midcingulate cortex (MCC) and dorsolateral prefrontal (dlPFC) are associated with multiple cognitive functions, including rapid long-term adaptive processes. Here we show that DREADD-mediated activation of MCC to dlPFC projection in macaques led increased engagement a foraging task, but did not alter their trial-to-trial strategy. We conclude critical role for MCC-dlPFC pathway is temporally extended control behaviour rather than adaptation.