PlasmodiumRepetome: A mysterious space with a wealth of information

• DOI: 10.1101/2025.04.14.647515
• Publication Date: 2025-04-23T16:09:08Z
• Authors: Satinder Kaur; Vikash Kumar; Karanbir Singh; Ankita Behl; Arpna; Prakash Chandra M...; Rachna Hora

ABSTRACT Eukaryotic proteomes harbour repetitive stretches of amino acids that may play critical roles in the biology organism. While several tandem repeats (TR) are known to contribute protein structure and function, information about vast majority repeat regions remains obscure. In this article, we have analysed content different Plasmodium species found leading human malaria-causing P. falciparum (Pf) vivax be exceptionally rich TR (>40% containing proteins). Detailed analysis Pf ‘repetome’ showed intracellular parasite carry longer TRs, which were present exported proteins important for survival immune evasion. The enriched acidic asparagine (Asn), where Asn was more abundant short intermediate suggesting an evolutionary bias influenced by replication slippage positive selection. Gene ontology helped us understand their cellular localization along with molecular biological processes they involved in. variable surface antigen families pathogenic like cytoadherence, evasion etc. had low within seroreactive peptides. Three-dimensional predictions revealed adopt ordered super-secondary conformations facilitate intermolecular interactions. Overall, is a comprehensive study attempting gain insights on importance TRs malaria suggests novel route understanding function through characterization content.