Photocontrol of endogenous glycine receptors in vivo

• DOI: 10.1101/744391
• Publication Date: 2019-08-23T02:35:12Z
• Authors: Alexandre M.J. Go...; Karin Rustler; Galyna Maleeva; Alba Nin-Hill; Daniel Wutz; Antoni Bautista-B...; Xavier Rovira; Miquel Bosch; Elvira Mukhametova; Marat Mukhamedyarov; Frank Peiretti; Mercedes Alfonso-...; Carme Rovira; Burkhard König; Piotr Bregestovski; Pau Gorostiza
• Keywords: 0303 health sciences; 03 medical and health sciences

ABSTRACT Glycine receptors (GlyRs) are indispensable to maintain excitatory/inhibitory balance in neuronal circuits controlling reflex and rhythmic motor behaviors. Here we have developed Glyght, the first GlyR ligand controlled with light. It is selective over other cys-loop receptors, active vivo , displays an allosteric mechanism of action. The photomanipulation glycinergic neurotransmission opens new avenues understand inhibitory intact animals, develop drug-based phototherapies.