3D-Cardiomics: A spatial transcriptional atlas of the mammalian heart

• DOI: 10.1101/792002
• Publication Date: 2019-10-04T02:55:18Z
• Authors: Monika Mohenska; Nathalia M. Tan; Alex Tokolyi; Milena B. Furtado; Mauro W. Costa; Andrew J. Perry; Jessica Hatwell-H...; Karel van Duijven...; Hieu T. Nim; Susan K. Nilsson; David R. Powell; Nadia A. Rosenthal; Fernando J. Rossello; Mirana Ramialison; Jose M. Polo
• Keywords: Expression (computer science)

Abstract Understanding spatial gene expression and regulation is key to uncovering developmental physiological processes, during homeostasis disease. Numerous techniques exist gain information, but very few utilise intuitive true-to-life three-dimensional representations analyze visualize results. Here we combined transcriptomics with 3D modelling represent interrogate, transcriptome-wide, location in the mouse adult heart. Our study has unveiled specific subsets of genes that display complex organ sub-compartments. Also, created a web-based user interface for transcriptome analysis visualization. The application may be accessed from http://3d-cardiomics.erc.monash.edu/ .