Genetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach

• DOI: 10.1101/804419
• Publication Date: 2019-10-15T22:23:25Z
• Authors: Juliana Afonso; Marina Rufino Sal...; Antonio Reverter; Wellison Jarles d...; Aline Silva Mello...; Andressa Oliveira...; Juliana Petrini; Marcela M. de Souza; Luiz Lehmann Cout...; Gerson Barreto Mo...; Adhemar Zerlotini; Caio Fernando Gro...; Ana Rita Araújo N...; Luciana Correia d...
• Keywords: Beef Cattle

Abstract Mineral amount in bovine muscle affect meat quality, growth, health and reproductive traits beef cattle. To better understand the genetic basis of this phenotype, we implemented new applications use for two complementary algorithms: partial correlation information theory (PCIT) regulatory impact factor (RIF), by including GEBVs as part input. We used PCIT to determine putative relationships based on significant associations between gene expression mineral amount. Then, RIF was genes miRNA over also investigated over-represented pathways, well evidences from previous studies carried same population, e.g. NOX1 , whose positively correlated Zn described regulated humans. With methodology, were able identify genes, miRNAs pathways not yet important The results support hypothesis that extracellular matrix interactions are core regulator cells. Putative regulators here add hypothesis, expanding molecular minerals.