Identification of a novel mechanism of regulation of Ah (dioxin) receptor function

• DOI: 10.1101/gad.13.1.20
• Publication Date: 2008-02-20T22:15:26Z
• Authors: Junsei Mimura; Masatsugu Ema; Kazuhiro Sogawa; Yoshiaki Fujii-Ku...
• Keywords: Xenobiotic

Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo- p -dioxin on host animals. In addition to induction drug-metabolizing enzymes, the liganded AhR complex was found activate gene expression designated repressor (AhRR), which inhibits function by competing with for dimerizing Arnt and binding XRE sequence. Thus, AhRR form regulatory circuit in xenobiotic signal transduction pathway provide novel mechanism regulation may determine tissue-specific sensitivity pollutants.