The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

• DOI: 10.1101/gad.1777409
• Publication Date: 2009-06-01T18:27:43Z
• Authors: Jason T. Huse; Cameron Brennan; Dolores Hambardzu...; Boyoung Wee; John Pena; Sara H. Rouhanifard; Cherin Sohn-Lee; Carlos le Sage; Reuven Agami; Thomas Tuschl; Eric C. Holland
• Keywords: Tensin

Activated oncogenic signaling is central to the development of nearly all forms cancer, including most common class primary brain tumor, glioma. Research over last two decades has revealed particular importance Akt pathway, and its molecular antagonist PTEN (phosphatase tensin homolog), in process gliomagenesis. Recent studies have also demonstrated that microRNAs (miRNAs) may be responsible for modulation cancer-implicated genes tumors. Here we report identification miR-26a as a direct regulator expression. We show frequently amplified at DNA level human glioma, often association with monoallelic loss. Finally, demonstrate miR-26a-mediated repression murine glioma model both enhances de novo tumor formation precludes loss heterozygosity locus. Our results document new epigenetic mechanism regulation further highlight dysregulation crucial these