A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

• DOI: 10.1101/gad.186411.111
• Publication Date: 2012-03-20T04:19:08Z
• Authors: Camille Simon; Jalila Chagraoui; Jana Krosl; Patrick Gendron; Brian Wilhelm; Sébastien Lemieux; Geneviève Boucher; Pierre Chagnon; Simon Drouin; Raphaëlle Lambert; Claude Rondeau; Annie Bilodeau; Sylvie Lavallée; Martin Sauvageau; Josée Hébert; Guy Sauvageau
• Keywords: PRC2; Polycomb-group proteins

In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion enhancer zeste homolog 2 ( Ezh2 ). Tumor cells little residual H3K27 trimethylation marks compared controls. EZH2 is a component PRC2 Polycomb group protein complex, which associated DNA methyltransferases. Using next-generation sequencing, identify alteration gene expression levels and acquired mutations PRC2-associated genes DNMT3A JARID2 ) human adult T-ALL. Together, these studies document that deregulation leads to development mouse, likely human,