The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons

• DOI: 10.1101/gad.259119.115
• Publication Date: 2015-06-11T10:21:35Z
• Authors: Wen-Yang Lin; Claire Williams; Connie Yan; Tatyana Koledachkina; Kory Luedke; Jesse Dalton; Sam Bloomsburg; Nicole Morrison; Kent E. Duncan; Charles C. Kim; Jay Z. Parrish
• Keywords: Dendrite (mathematics); Genetic screen

Dendrites exhibit enormous diversity in form and can differ size by several orders of magnitude even a single animal. However, whether neurons with large dendrite arbors have specialized mechanisms to support their growth demands is unknown. To address this question, we conducted genetic screen for mutations that differentially affected different-sized arbors. From screen, identified mutant selectively affects without affecting small or the animal overall. This disrupts putative amino acid transporter, Pathetic (Path), localizes cell surface endolysosomal compartments neurons. Although Path broadly expressed nonneuronal cells, mutation path impinges on nutrient responses protein homeostasis specifically but not other cells. Altogether, our results demonstrate molecular exist define as founding member program.