New Target Regions for Human Hypertension via Comparative Genomics

• DOI: 10.1101/gr.10.4.473
• Publication Date: 2002-07-27T00:00:34Z
• Authors: Monika Stoll; Anne E. Kwitek-Black; Allen W. Cowley; Eugenie L. Harris; Stephen B. Harrap; José E. Krieger; Morton P. Printz; Abraham P. Provoost; Jean Sassard; Howard J. Jacob
• Keywords: Linkage Disequilibrium; Genome-wide Association Study; Human disease; Genetic Association; Comparative Genomics; Functional Genomics; Candidate gene

Models of human disease have long been used to understand the basic pathophysiology and facilitate discovery new therapeutics. However, as models there debates about utility these their ability mimic clinical at phenotypic level. The application genetic studies both humans model systems allows for a paradigm, whereby novel comparative genomics strategy combined with correlates can be bridge between relevance utility. This study presents genomic map “candidate hypertension loci in humans” based on translating QTLs rat human, predicting 26 chromosomal regions genome that are very likely harbor genes. predictive power appears robust, several also implicated mouse, suggesting represent primary targets development SNPs linkage disequilibrium testing and/or provide means select specific additional functional