The landscape of genomic imprinting across diverse adult human tissues

• DOI: 10.1101/gr.192278.115
• Publication Date: 2015-05-08T03:11:19Z
• Authors: Yael Baran; Meena Subramaniam; Anne Biton; Taru Tukiainen; Emily K. Tsang; Manuel A. Rivas; Matti Pirinen; Maria Gutierrez-A...; Kevin S. Smith; Kim R. Kukurba; Rui Zhang; Celeste Eng; Dara G. Torgerson; Cydney Urbanek; ; Jin Billy Li; Jose R. Rodriguez...; Esteban G. Burchard; Max A. Seibold; Daniel G. MacArthur; Stephen B. Montgo...; Noah A. Zaitlen; Tuuli Lappalainen
• Keywords: Imprinting (psychology); Genomic Imprinting

Genomic imprinting is an important regulatory mechanism that silences one of the parental copies a gene. To systematically characterize this phenomenon, we analyze tissue specificity from allelic expression data in 1582 primary samples 178 individuals Genotype-Tissue Expression (GTEx) project. We 42 genes, including both novel and previously identified genes. Tissue widespread, gender-specific effects are revealed small number genes muscle with stronger males. IGF2 shows maternal brain instead canonical paternal elsewhere. Imprinting appears to have only subtle impact on tissue-specific levels, lacking systematic difference between tissues imprinted biallelic expression. In summary, our characterization adult highlights variation individuals, tissues.