Memory Consolidation for Contextual and Auditory Fear Conditioning Is Dependent on Protein Synthesis, PKA, and MAP Kinase

• DOI: 10.1101/lm.6.2.97
• Publication Date: 2021-11-11T13:56:17Z
• Authors: Glenn E. Schafe; Nicole V. Nadel; Gregory M. Sullivan; Alexander Harris; Joseph E. LeDoux
• Keywords: Anisomycin; Long-term memory

Fear conditioning has received extensive experimental attention. However, little is known about the molecular mechanisms that underlie fear memory consolidation. Previous studies have shown long-term potentiation (LTP) exists in pathways to be relevant and modifies neural processing these a manner similar LTP induction. The present experiments examined whether inhibition of protein synthesis, PKA, MAP kinase activity, treatments block LTP, also interfere with consolidation conditioning. Rats were injected intraventricularly Anisomycin (100 or 300 microg), Rp-cAMPS (90 180 PD098059 (1 3 microg) prior assessed for retention contextual auditory both within an hour 24 hr later. Results indicated injection compounds selectively interfered fear, while leaving short-term intact. Additional control groups this effect was likely due impaired rather than nonspecific effects drugs on expression. suggest may share common mechanisms.