The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer

• DOI: 10.1101/mcs.a006275
• Publication Date: 2023-08-31T16:55:38Z
• Authors: Majd Al Assaad; Gunes Gundem; Benjamin Liechty; Andrea Sboner; Juan Medina; Elli Papaemmanuil; Cora N. Sternberg; Asher Marks; Mark M. Souweidane; Jeffrey P. Greenf...; Ivy Tran; Matija Snuderl; Olivier Elemento; Marcin Imielinski; David J. Pisapia; Juan Miguel Mosquera
• Keywords: Pilocytic astrocytoma; Pediatric cancer; Brain tumor; Targeted Therapy

Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy an unresectable suprasellar tumor, negative for