Nonlinear Pressure Dependence of the Interaction Potential of Dense Protein Solutions

• DOI: 10.1103/physrevlett.106.178102
• Publication Date: 2011-04-26T15:32:51Z
• Authors: Martin A. Schroer; Jonas Markgraf; D. C. Florian Wie...; Christoph J. Sahle; Johannes Möller; Michael Paulus; Metin Tolan; Roland Winter
• Keywords: Protein Folding; info:eu-repo/classification/ddc/550; X-Rays; 02 engineering and technology; Hydrogen-Ion Concentration; Protein Structure, Secondary; Solutions; Models, Chemical; Nonlinear Dynamics; Pressure; Scattering, Radiation; Muramidase; 0210 nano-technology

The influence of pressure on the structure and protein-protein interaction potential dense protein solutions was studied analyzed using small-angle x-ray scattering in combination with a liquid state theoretical approach. structural as well parameters lysozyme are affected by nonlinear way. properties water lead to modification interactions below 4 kbar, which might have significant consequences for stability proteins extreme natural environments.