The ArabidopsisBAP1andBAP2Genes Are General Inhibitors of Programmed Cell Death

• DOI: 10.1104/pp.107.100800
• Publication Date: 2007-07-14T00:34:16Z
• Authors: Huijun Yang; Shuhua Yang; Yongqing Li; Jian Hua
• Keywords: Hypersensitive response

Abstract Here we identify the BAP1 and BAP2 genes of Arabidopsis (Arabidopsis thaliana) as general inhibitors programmed cell death (PCD) across kingdoms. These two homologous encode small proteins containing a calcium-dependent phospholipid-binding C2 domain. its functional partner BON1 have been shown to negatively regulate defense responses disease resistance gene SNC1. Genetic studies here reveal an overlapping function in control. The loss induces accelerated hypersensitive but does not compromise plant growth or confer enhanced virulent bacterial oomycete pathogens. both confers seedling lethality mediated by PAD4 EDS1, regulators responses. Overexpression with their inhibits PCD induced pathogens, proapototic BAX, superoxide-generating paraquat Nicotiana benthamiana. Moreover, expressing yeast (Saccharomyces cerevisiae) alleviates hydrogen peroxide. Thus, BAP negative biotic abiotic stimuli including reactive oxygen species. dual roles BON repressing inhibiting has implications understanding evolution innate immunity.