Research on the effects of L-carnitine and trans-chalcone on endoplasmic reticulum stress and oxidative stress in high-fructose corn syrup-fed rats

• DOI: 10.1108/nfs-05-2020-0162
• Publication Date: 2020-06-29T16:29:27Z
• Authors: Velid Unsal; Köksal Deveci; Zeliha Cansel Ozmen; Mehmet Kemal Tumer
• Keywords: Malondialdehyde; Chalcone; Homeostasis

Purpose The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. deterioration endoplasmic reticulum (ER) homeostasis is called ER stress. Glucose-regulated protein-78 (GRP-78) and X-box binding protein-1 (XBP-1) are key markers stress therapeutic targets diseases. Sterol regulatory element protein-1c (SREBP-1c) most important transcription factor that regulates expression enzymes for fatty acid synthesis. purpose this paper to research L-carnitine trans-chalcone oxidative parameters, explore potential molecules. Design/methodology/approach Forty male wistar albino rats randomly selected were divided into five groups. All groups fed with standard chow (ad libitum). While Group I was drinking water, II, III, IV V water containing 15% HFCS. given V, both dissolved DMSO intraperitoneally. III not anything additional. Findings amount consumption HFCS-fed has increased, feed decreased. weights in II have increased significantly compared ( p = 0.001, 0.001 respectively). In GRP78, XBP-1; malondialdehyde level < 0.041); total cholesterol, triglyceride, LDL levels 0.009, respectively) significantly. Originality/value To best authors’ knowledge, study first report show excessive HFCS causes antioxidant antiobesity properties trans chalcone been demonstrated. Extensive experimental clinical studies should be conducted.