Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease‐modifying treatment, 2003–17

• DOI: 10.1111/1471-0528.16957
• Publication Date: 2021-10-01T17:03:02Z
• Authors: OB Esan; DK Schlüter; R Phillips; R Cosgriff; S Paranjothy; D Williams; R Norman; SB Carr; J Duckers; D Taylor‐Robinson
• Keywords: Live birth

To compare pregnancy rates and outcomes for women with cystic fibrosis in the UK those of general population assess effect introduction disease-modifying treatment.A population-based longitudinal study, 2003-17.United Kingdom.Women aged 15-44 years (CF) Registry compared England Wales.We calculated live-birth CF Wales. For we before after ivacaftor was introduced 2013. We further used registry data to mothers CF, relationship between maternal pre-pregnancy lung function nutritional status child gestational age.Pregnancy age.Of 3831 661 reported 818 pregnancies. Compared population, rate 3.3 times lower (23.5 versus 77.7 per 1000 woman-years); 3.5 (17.4 61.4 woman-years) 70% pregnancies resulting live births; termination were also (9% 22%). Pregnancy increased post-ivacaftor eligible from 29.7 45.7 woman-years. There no association function/nutrition are about one-third favourable outcomes, post-ivacaftor.Pregnancy a third Wales births. Ivacaftor increases rate.