Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes

• DOI: 10.1111/1753-0407.13292
• Publication Date: 2022-07-05T05:45:14Z
• Authors: Rui Zhang; Jin Chen; Yanqin Xiong; Lihong Wang; Xinmei Huang; Tiange Sun; Bingbing Zha; Yueyue Wu; Cuili Yan; Shufei Zang; Qin Zhou; Zhe Huang; Jun Liu
• Keywords: Absolute neutrophil count; Cumulative incidence

This study aims to investigate the potential association of peripheral inflammatory blood cell parameters with incidence and progression chronic kidney disease (CKD) in patients diabetes.The cross-sectional included 1192 subjects diabetes derived from one center. The cohort 2060 another two centers followed up for 4 years. Logistic regression Cox proportional hazards models were used evaluate CKD.In study, neutrophil count performed best as an independent risk factor CKD (odds ratio 2.556 [95% confidence interval 1.111, 5.879]) even after 1:1 case-control matching age, gender, history high pressure duration diabetes. Spline revealed a significant linear continuous excess 3.6 × 109 /L. In grouped based on tertile neutrophil-to-lymphocyte ratio. analysis results showed that only was independently associated (the highest group vs. lowest group, hazard 2.293 1.260, 4.171]) fully adjusting confounders. cumulative gradually increased increasing (53 (7.7%) 60 (8.2%) middle 78 (12.2%) group).This suggested is diabetes.背景: 本研究旨在探讨糖尿病人中外周血炎性细胞参数与慢性肾脏疾病(CKD)的发生和发展之间的潜在相关性。 方法: 以1192名来自同一研究中心的受试者作为横断面研究。来自另外两个中心的2060名受试者随访4年，进入队列研究。采用Logistic回归和COX比例风险模型评价外周血炎性细胞与CKD的相关性。 结果: 在横断面研究中，即使在年龄、性别、高血压病史和糖尿病病程进行1:1病例对照匹配后，中性粒细胞计数仍然是CKD的最相关的独立危险因素(OR 2.556[95%CI 1.111，5.879])。样条回归显示CKD发病率与中性粒细胞计数持续超过3.6×109 /L呈显著线性相关。在队列研究中，受试者根据中性粒细胞计数和中性粒细胞/淋巴细胞比率的三分位进行分组。COX回归分析结果显示，在完全校正潜在混杂因素后，只有中性粒细胞计数与CKD进展独立相关(最高组vs.最低组，HR 2.293[95%CI 1.260，4.171])。随着中性粒细胞计数的增加，糖尿病患者CKD进展的累积发生率逐渐增加，最低组53例(7.7%)，中间组60例(8.2%)，最高组78例(12.2%)。 结论: 本研究提示中性粒细胞计数是糖尿病患者CKD进展的独立危险因素。.