Successful autologous hematopoietic stem cell transplantation for a patient with rapidly progressive localized scleroderma

• DOI: 10.1111/1756-185x.12555
• Publication Date: 2015-04-30T11:50:24Z
• Authors: Velu Nair; Ajay Sharma; Sanjeevan Sharma; Satyaranjan Das; Darshan S. Bhakuni; Krishnan Narayanan; Vivek Nair; Subramanian Shankar
• Keywords: Scleroderma (fungus); Disfigurement

Abstract Autologous hematopoietic stem cell transplant ( HSCT ) for rapidly progressive disease has not been reported in localized scleroderma. Our patient, a 16‐year‐old girl had an aggressive variant of scleroderma, mixed subtype (linear‐generalized) with Parry Romberg syndrome, no internal organ involvement, that was unresponsive to immunosuppressive therapy and causing rapid disfigurement. She administered autologous June 2011 maintained drug‐free remission excellent functional status at almost 3.5 years follow‐up.