Domain‐specific cognitive dysfunction after cardiac surgery. A secondary analysis of a randomized trial

• DOI: 10.1111/aas.13343
• Publication Date: 2019-03-20T06:32:28Z
• Authors: Anne G. Vedel; Frederik Holmgaard; Volkert Siersma; Annika Langkilde; Olaf B. Paulson; Hanne B. Ravn; Jens Chr. Nilsson; Lars S. Rasmussen
• Keywords: Postoperative cognitive dysfunction

Background Brain injury and cognitive dysfunction are serious complications after cardiac surgery. In the perfusion pressure cerebral infarcts (PPCI) trial, we allocated surgery patients to a mean arterial of either 70‐80 mm Hg (high‐target) or 40‐50 (low‐target) during cardiopulmonary bypass. this secondary analysis, aimed assess potential differences in domain‐specific patterns deterioration between allocation groups investigate any associations postoperative (POCD) with diffusion‐weighted magnetic resonance imaging (DWI)‐detected brain lesions. Methods Of 197 randomized PPCI 89 low‐target group 80 high‐target had complete DWI datasets, 92 data for an evaluation function at discharge respectively. Cognitive was assessed prior surgery, 3 months. obtained baseline on days 6. Results We found no statistically significant two when comparing proportion over pre‐defined critical level seven individual test variables discharge. Significant most common tests thought flexibility interference susceptibility least memory test. POCD more frequent DWI‐positive lesions (OR adjusted age allocation: 2.24 [95% CI 1.48‐3.00], P = 0.036). Conclusions Domain‐specific were comparable groups. A association seen POCD.