Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation

• DOI: 10.1111/acel.12616
• Publication Date: 2017-07-06T00:08:54Z
• Authors: Jun Ren; Lifang Yang; Li Zhu; Xihui Xu; Asli F. Ceylan; Wei Guo; Jian Yang; Yingmei Zhang
• Keywords: Life span

Aging is accompanied with unfavorable geometric and functional changes in the heart involving dysregulation of Akt autophagy. This study examined impact Akt2 ablation on life span cardiac aging as well mechanisms involved a focus autophagy mitochondrial integrity. Cardiac geometry, contractile, intracellular Ca