Insula and amygdala resting‐state functional connectivity differentiate bipolar from unipolar depression

• DOI: 10.1111/acps.12724
• Publication Date: 2017-03-29T02:42:41Z
• Authors: E. Ambrosi; D. B. Arciniegas; A. Madan; K. N. Curtis; M. A. Patriquin; R. E. Jorge; G. Spalletta; J. C. Fowler; B. C. Frueh; R. Salas
• Keywords: Depression

Objective Distinguishing depressive episodes due to bipolar disorder ( BD ) or major MDD solely on clinical grounds is challenging. We aimed at comparing resting‐state functional connectivity (rs FC of regions subserving emotional regulation in similarly depressed and . Method enrolled 76 in‐patients , n = 36; 40) 40 healthy controls (HC). A seed‐based approach was used identify showing different rs with the insula amygdala. Insular amygdalar parcellations were then performed along diagnostic accuracy main findings. Results Lower between left mid‐dorsolateral prefrontal cortex bilateral right frontopolar FPPFC observed compared HC These results driven by dorsal anterior posterior PI ). amygdala hippocampus centromedial laterobasal Left /right FPPC showed 78% differentiating Conclusion distinguished The differences suggest possibility differential pathophysiological mechanisms dysfunction unipolar depression.