Triple monoamine uptake inhibitors demonstrate a pharmacologic association between excessive drinking and impulsivity in high‐alcohol‐preferring (HAP) mice

• DOI: 10.1111/adb.12100
• Publication Date: 2013-10-14T03:16:48Z
• Authors: David S. O'Tousa; Kaitlin T. Warnock; Liana M. Matson; Ojas A. Namjoshi; Michael Van Linn; Veera Venkata Tir...; Meredith E. Halcomb; James Cook; Nicholas J. Grahame; Harry L. June
• Keywords: Binge drinking; Delay Discounting

Abstract Approximately 30% of current drinkers in the United States drink excessively, and are referred to as problem/hazardous drinkers. These individuals, who may not meet criteria for alcohol abuse or dependence, comprise binge, heavy drinkers, both. Given their high prevalence, interventions that reduce risk binge drinking have important public health implications. Impulsivity has been repeatedly associated with excessive clinical literature. As impulsivity is correlated with, play a critical role in, initiation maintenance drinking, this behavior be an target therapeutic intervention. Hence, better understanding pharmacological treatments capable attenuating markedly improve outcomes. The high‐alcohol‐preferring ( HAP ) mice represent strong rodent model study relationship between recent evidence indicates they consume levels throughout active cycle innately impulsive. Using model, present demonstrates triple monoamine uptake inhibitors TUIs amitifadine DOV 102, 677 effectively attenuate assessed via 24‐hour free‐choice assay, measured by delay discounting procedure. In contrast, 3‐ PBC , GABA ‐ A α1 preferring ligand mixed agonist‐antagonist properties, attenuates without affecting impulsivity. findings suggest mice, pathways predominate common mechanism underlying while ergic system more salient regulating drinking. We further propose such used treat co‐occurrence