Characterization of white matter integrity deficits in cocaine‐dependent individuals with substance‐induced psychosis compared with non‐psychotic cocaine users

• DOI: 10.1111/adb.12363
• Publication Date: 2016-02-01T08:56:32Z
• Authors: Taylor S. Willi; Alasdair M. Barr; Kristina Gicas; Donna J. Lang; Fidel Vila‐Rodriguez; Wayne Su; Allen E. Thornton; Olga Leonova; Chantelle J. Gies...; Ric M. Procyshyn; Alexander Rauscher; William G. MacEwan; William G. Honer; William J. Panenka
• Keywords: Corona radiata (embryology)

Abstract With sufficient drug exposure, some individuals develop transient psychotic symptoms referred to as ‘substance‐induced psychosis’ (SIP), which closely resemble the observed in schizophrenia spectrum disorders. The comparability presentation between SIP and schizophrenias suggests that similar underlying neural deficits may contribute emergence of psychosis across these Only a small number studies have investigated structural alterations SIP, all been limited volumetric imaging methods, with none controlling for effects chronic exposure. To investigate white matter abnormalities associated diffusion tensor was employed group cocaine‐associated (CAP; n = 24) cocaine‐dependent non‐psychotic (CDN) ( 43). Tract‐based spatial statistics used differences parameters. CAP showed significantly lower fractional anisotropy values than CDN p < 0.05) voxels within tracts fronto‐temporal, fronto‐thalamic interhemispheric pathways. greatest integrity were present corpus callosum, corona radiata, bilateral superior longitudinal fasciculi inferior fasciculi. Additionally, had higher radial diffusivity subset previously mentioned These results are first description sample indicate pathways be shared factor expression different forms psychosis.