Plasma concentrations of oleoylethanolamide and other acylethanolamides are altered in alcohol-dependent patients: effect of length of abstinence

• DOI: 10.1111/adb.12408
• Publication Date: 2016-05-24T05:06:39Z
• Authors: Nuria Garcia-Marc...; Francisco J. Pavon; Antoni Pastor; Pedro Araos; Maria Pedraz; Pablo Romero-Sanchiz; Montserrat Calado; Juan Suarez; Estela Castilla-O...; Laura Orio; Anna Boronat; Marta Torrens; Gabriel Rubio; Rafael de la Torre; Fernando Rodrigue...; Antonia Serrano
• Keywords: Alcohol Dependence

Acylethanolamides are a family of endogenous lipid mediators that involved in physiological and behavioral processes associated with addiction. Recently, oleoylethanolamide (OEA) has been reported to reduce alcohol intake relapse rodents but the contribution OEA other acylethanolamides addiction humans is unknown. The present study aimed characterize plasma dependence. Seventy-nine abstinent alcohol-dependent subjects (27 women) recruited from outpatient treatment programs age-/sex-/body mass-matched healthy volunteers (28 were clinically assessed diagnostic interview PRISM according DSM-IV-TR after blood extraction for quantification acylethanolamide concentrations plasma. Our results indicate all significantly increased patients compared control (p < 0.001). A logistic model based on these was developed distinguish controls included OEA, arachidonoylethanolamide (AEA) docosatetraenoylethanolamide (DEA), providing high discriminatory power area under curve [AUC = 0.92 (95%CI: 0.87-0.96), p 0.001]. Additionally, we found significant effect duration abstinence AEA DEA using regression 0.05, 0.01 0.001, respectively), which confirmed by negative correlation (rho -0.31, -0.40 -0.44, respectively). However, not influenced severity, problematic use or diagnosis psychiatric comorbidity. support preclinical studies suggest altered alcohol-dependence during might act as potential markers predicting length abstinence.