Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference

• DOI: 10.1111/adb.12975
• Publication Date: 2020-10-23T08:59:37Z
• Authors: Cheng Yang; Xiaoya Fu; Wei Hao; Xiaojun Xiang; Tieqiao Liu; Bao‐Zhu Yang; Xiaojie Zhang
• Keywords: Conditioned place preference; Dysbiosis; Akkermansia; Methamphetamine; Gut–brain axis

Abstract Methamphetamine (MA) is a potent stimulant and notoriously addictive. Individuals respond to MA effects differently thus have varying susceptible risk of developing use disorder. Cumulative evidence has indicated that gut dysbiosis contributes behavioral response drug effects. However, the role microbiota in disorder remained elusive. Using an MA‐induced conditioned place preference (CPP) rat model, we administrated same dose rats, which then showed distinct preferences drug‐related place, indicating their different responses MA. From all MA‐exposed eight with highest CPP scores were labeled as group high (H‐CPP), lowest low (L‐CPP). By 16S ribosomal RNA (rRNA) sequencing, found compositions differed between H‐CPP L‐CPP. Specifically, Akkermansia was significantly higher positively correlated scores. Notably, L‐CPP composition prior training; Ruminococcus dominant phylotype at baseline. More importantly, rats pretreated by antibiotics stronger than did controls. Our study demonstrates associated CPP, might be important modulators for behavior vulnerability