Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol‐dependent subjects and individuals at high risk: A multimodal magnetic resonance spectroscopy and positron emission tomography study

• DOI: 10.1111/adb.13424
• Publication Date: 2024-06-20T07:46:15Z
• Authors: Gianna Spitta; Tobias Gleich; Annika Rosenthal; Florian Schubert; Semiha Aydin; Andreas Heinz; Ralph Buchert; Jürgen Gallinat
• Keywords: Ventral striatum

Abstract Background The association of impaired dopaminergic neurotransmission with the development and maintenance alcohol use disorder is well known. More specifically, reduced dopamine D2/3 receptors in striatum subjects dependence (AD) compared to healthy controls have been found previous studies. Furthermore, alterations gamma‐aminobutyric acid (GABA) glutamate (Glu) levels anterior cingulate cortex (ACC) AD documented several However, interaction between cortical Glu striatal has not investigated thus far. Methods This study receptor availability via 18F‐fallypride positron emission tomography (PET) GABA as magnetic resonance spectroscopy (MRS) 19 detoxified subjects, 18 (low risk, LR) individuals at high risk (HR) for developing AD, carefully matched sex, age smoking status. Results We a significant negative correlation ACC associative LR but or HR individuals. Contrary our expectations, we did observe concentrations availability. Conclusions results may reflect potential regulatory mechanisms on mesolimbic their disruption mirroring complex neurotransmitter interactions associated pathogenesis addiction. first combining PET MRS risk.