Influence of alcohol and acetaldehyde on cognitive function: findings from an alcohol clamp study in healthy young adults

• DOI: 10.1111/add.15733
• Publication Date: 2021-11-04T15:00:11Z
• Authors: Fumihiko Ueno; Sachio Matsushita; Sachiko Hara; Shunji Oshima; Sungwon Roh; Vijay A. Ramchandani; Masaru Mimura; Hiroyuki Uchida
• Keywords: Adult; Young Adult; 0303 health sciences; 03 medical and health sciences; Cognition; Ethanol; Humans; Blood Alcohol Content; Acetaldehyde; Neuropsychological Tests; 3. Good health

To investigate the acute effects of intravenous alcohol and its metabolite acetaldehyde on cognitive function in healthy individuals.Experimental pre-test/post-test design.Kurihama Medical Addiction Center, Japan.A total 298 Japanese people age 20 to 24 years.Participants underwent an infusion with a target blood concentration (BAC) 0.50 mg/mL for 180 minutes. Participants completed continuous performance test (CPT) sustained attention, paced auditory serial addition (PASAT) working memory, reaction time (RTT) speed/accuracy, along BAC (BAAC) at baseline, 60 minutes.Although was maintained during infusion, BAAC peaked 30 minutes then gradually declined (η2 = 0.18, P < 0.01). The CPT scores worsened, changes between 0 were correlated (correct detection, η2 0.09, 0.01; r -0.34, omission errors, 0.08, 0.34, PASAT improved through minutes, whereas negatively (task one, 0.02, -0.25, task two, 0.03, -0.28, Although RTTs they not associated or BAAC. None these comparisons effect after controlling body height.Acetaldehyde exposure following appears have negative impact attention there seems be only minor moderate speed accuracy.