COVID‐19 complications among patients with opioid use disorder: a retrospective cohort study across five major NYC hospital systems

• DOI: 10.1111/add.16105
• Publication Date: 2022-12-02T16:57:55Z
• Authors: Noa Krawczyk; Bianca D. Rivera; Cale Basaraba; Thomas Corbeil; Bennett Allen; Katharina Schulte...; Brandy F. Henry; Harold A. Pincus; Frances R. Levin; Diana Martinez
• Keywords: Opioid Overdose; Drug overdose

Abstract Background and Aims Individuals with opioid use disorder (OUD) suffer disproportionately from COVID‐19. To inform clinical management of OUD patients, research is needed to identify characteristics associated COVID‐19 progression death among this population. We aimed investigate the role specific comorbidities on hospitalized patients. Design Retrospective cohort study merged electronic health records (EHR) five large private systems. Setting New York City, York, USA, 2011–21. Participants Adults a encounter or overdose diagnosis between March 2020 February 2021. Measurements Primary exposure included OUD/opioid overdose. Risk factors age, sex, race/ethnicity common medical, substance psychiatric known be severity. Outcomes hospitalization subsequent intubation, acute kidney failure, severe sepsis death. Findings Of 110 917 COVID‐19+ adults, 1.17% were ever diagnosed patients had higher risk [adjusted ratio (aRR) = 1.40, 95% confidence interval (CI) 1.33, 1.47], intubation odds (aOR) 2.05, CI 1.74, 2.42], failure (aRR 1.51, 1.34, 1.70), 2.30, 1.88, 2.81) 2.10, 1.84, 2.40). Among risks for worse outcomes being male; older; other than white, black Hispanic; having comorbid chronic disease, diabetes, obesity cancer. Protective asthma, hepatitis‐C pain. Conclusions Opioid appear have substantial COVID‐19‐associated morbidity mortality, particular treatments moderating risk.