A genome‐wide association study of heat stress‐associated SNPs in catfish

• DOI: 10.1111/age.12482
• Publication Date: 2016-08-02T17:03:03Z
• Authors: Y. Jin; T. Zhou; X. Geng; S. Liu; A. Chen; J. Yao; C. Jiang; S. Tan; B. Su; Z. Liu
• Keywords: Genome-wide Association Study; SNP; Genetic Association

Summary Heat tolerance is a complex and economically important trait for catfish genetic breeding programs. With global climate change, it becoming an increasingly trait. To better understand the molecular basis of heat stress, genome‐wide association study ( GWAS ) was carried out using 250 K SNP array with interspecific backcross progenies, which derived from crossing female channel male F1 hybrid (female × blue catfish). Three significant associated s were detected by performing EMMAX approach . The located on linkage group 14 explained 12.1% phenotypical variation. other two s, 16, 11.3 11.5% variation respectively. A total genes stress related functions within regions. Among them, five genes— TRAF 2 , FBXW 5 ANAPC UBR 1 KLHL 29— have known in protein degradation process through ubiquitination pathway. Other to include involved biosynthesis PRPF 4 SYNCRIP ), folding DNAJC25 molecule iron transport SLC 25A46 CLIC cytoskeletal reorganization COL 12A1 energy metabolism COX 7A2 PLCB processes. results provide fundamental information about pathways that useful further investigation into mechanisms stress. could be promising candidates selecting heat‐tolerant lines after validating their effects larger various populations.