The role of vitamin D receptor gene polymorphisms in the pathogenesis of Behçet's disease: A case‐control study in Turkish population

• DOI: 10.1111/ahg.12301
• Publication Date: 2019-02-07T13:43:50Z
• Authors: Nazli Ecem Dal; Pamir Cerci; Umit Olmez; Goksal Keskin
• Keywords: Pathogenesis; Turkish population

Abstract Background Behçet's disease (BD) is an inflammatory disorder characterized by oral aphthous lesions, uveitis, and genital ulcerations. The vitamin D receptor (VDR) has a crucial role in the pathogenesis of this because it mediates functions immune system. Alterations VDR expression related to polymorphic alleles gene may play pathogenic BD BD's clinical presentations. Methods 150 patients healthy controls were included genotyping was carried out polymerase chain reaction/restriction fragment length polymorphism. Results Significant differences between rs1544410, rs2228570, rs731236 genotypes observed (respectively, p = 0.04, 0.007, 0.012). characteristics evaluated with ocular lesions had higher percentage rs1544410 A ( 0.004), positive pathergy tests, arthritis more rs2228570 C than without these findings < 0.001, 0.021, 0.045). Conclusion polymorphisms possibly have through their effects on be associated increased risk several findings.