Role of adjuvant chemotherapy in T2N0M0 periampullary cancers

• DOI: 10.1111/ajco.12612
• Publication Date: 2016-12-28T10:06:44Z
• Authors: Vikas Ostwal; Caleb Harris; Bhawna Sirohi; Mahesh Goel; Munita Bal; Sadhana Kannan; Shailesh V Shrikh...
• Keywords: Adjuvant Chemotherapy; Adjuvant Therapy

Abstract Aims Surgery is the only modality that offers cure for periampullary adenocarcinoma. However, surgery alone results in failure 60% of patients. Studies have shown some benefits chemotherapy node positive and higher tumor stage We sought to determine role adjuvant early tumors with uninvolved nodes. Methods A retrospective analysis a prospectively maintained database patients resected from 2007 2014 was performed. Patients were studied adverse risk factors, therapy received survival. Results Of 105 patients, 14 85 observed. After median follow‐up over 36 months, overall 3‐year survival 94.2% observed group 100% (P = 0.33), disease‐free being 81.9% 90.9%, respectively, 0.477). Serum CA 19‐9 levels above 100 U/mL poor prognostic factor. Conclusion This study did not find benefit use chemotherapy, but might improve The needs further confirmation prospective trials.