Pre‐eclampsia is associated with reduced resolvin D1 and maresin 1 to leukotriene B4 ratios in the plasma

• DOI: 10.1111/aji.13206
• Publication Date: 2019-11-03T03:34:11Z
• Authors: Luiza Oliveira Pe...; Talita Adriana Pe...; Patrícia Campi Sa...; Lívia Cristina Ri...; Patrícia Nessrall...; Karina Braga Gomes; Lirlândia Pires S...; Luci Maria Sant'A...; André Talvani
• Keywords: Leukotriene B4; White blood cell

Omega-3 and omega-6 fatty acids can be endogenously converted into mediators with pro-inflammatory (eg, leukotriene B4/LTB4) or anti-inflammatory/pro-resolving activities resolvin D1/RvD1 maresin 1/MaR1). Recent data indicate an imbalance of LTB4 MaR1 levels in pre-eclampsia (PE), but the relative production these mediators, including RvD1, role disease pathogenesis remain unclear. Therefore, this study aimed to investigate plasma LTB4, pregnant women without PE non-pregnant controls their association clinical/laboratory parameters women.LTB4, were measured by competitive enzyme immunoassay 19 non-pregnant, 20 normotensive pregnant, 21 women.Plasma concentrations higher RvD1 lower than women, who presented similar women. did not differ among groups. Pre-eclampsia had decreased RvD1/LTB4 MaR1/LTB4 ratios. Considering only group, positive correlations observed all tested, between white blood cell count creatinine levels. However, lipid correlated negatively body mass index before pregnancy. also maternal age.Our findings suggest that state results systemic overproduction relation MaR1, may involved pathogenesis.