Donor Age and Early Graft Failure After Lung Transplantation: A Cohort Study

• DOI: 10.1111/ajt.12428
• Publication Date: 2013-08-26T16:52:57Z
• Authors: M.R. Baldwin; E.R. Peterson; I. Easthausen; I. Quintanilla; E. Colago; J.R. Sonett; F. D’Ovidio; J. Costa; J.M. Diamond; J.D. Christie; S.M. Arcasoy; D.J. Lederer
• Keywords: Adult; Aged, 80 and over; Graft Rejection; Lung Diseases; Male; Adolescent; Graft Survival; Age Factors; Middle Aged; Prognosis; 3. Good health; Survival Rate; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Risk Factors; Humans; Female; Primary Graft Dysfunction; Aged; Follow-Up Studies; Lung Transplantation; Retrospective Studies

Lungs from older adult organ donors are often unused because of concerns for increased mortality. We examined associations between donor age and transplant outcomes among 8860 lung recipients using Organ Procurement Transplantation Network Lung Transplant Outcomes Group data. used stratified Cox proportional hazard models generalized linear mixed to examine both 1-year graft failure primary dysfunction (PGD). The rate was similar lungs 18–64 years, but severely ill (Lung Allocation Score [LAS] >47.7 or use mechanical ventilation) 56–64 years had rates (p-values interaction = 0.04 0.02, respectively). Recipients <18 ≥65 (adjusted ratio [HR] 1.23, 95% CI 1.01–1.50 adjusted HR 2.15, 1.47–3.15, Donor not associated with the risk PGD. In summary, 56 64 may be safe candidates without a high LAS pediatric is small increase in early failure.