Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients
Adult
Graft Rejection
Male
Graft Survival
Calcinosis
Middle Aged
Pulse Wave Analysis
Kidney Function Tests
Prognosis
Kidney Transplantation
3. Good health
03 medical and health sciences
Calcification, Physiologic
Postoperative Complications
0302 clinical medicine
Cardiovascular Diseases
Risk Factors
Humans
Kidney Failure, Chronic
Female
Aged
Follow-Up Studies
Glomerular Filtration Rate
DOI:
10.1111/ajt.13443
Publication Date:
2015-09-16T20:28:35Z
AUTHORS (8)
ABSTRACT
Calcification of the vasculature is associated with cardiovascular disease and death in kidney transplant recipients. A novel functional blood test measures calcification propensity by quantifying transformation time (T50) from primary to secondary calciprotein particles. Accelerated T50 indicates a diminished ability serum resist calcification. We measured 1435 patients 10 weeks after transplantation during 2000–2003 (first era) 2009–2012 (second era). Aortic pulse wave velocity (APWV) was at week 1 year 589 second era. diabetes, deceased donor, first transplant, rejection, stronger immunosuppression, era, higher phosphate lower albumin. not progression APWV. During median follow-up 5.1 years, 283 died, 70 myocardial infarction, cardiac failure or sudden death. In Cox regression models, accelerated strongly independently both all-cause mortality, low versus high quartile: hazard ratio 1.60 (95% confidence interval [CI] 1.00–2.57), ptrend= 0.03, 3.60 CI 1.10–11.83), ptrend = 0.02, respectively. conclusion, mortality recipients, potentially via nonAPWV-related pathway. Whether therapeutic improvement improves outcome awaits clarification randomized trial.
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