Living donor liver transplantation for biliary atresia: An analysis of 2085 cases in the registry of the Japanese Liver Transplantation Society

• DOI: 10.1111/ajt.14489
• Publication Date: 2017-09-10T11:16:37Z
• Authors: Mureo Kasahara; Koji Umeshita; Seisuke Sakamoto; Akinari Fukuda; Hiroyuki Furukawa; Shotaro Sakisaka; Eiji Kobayashi; Eiji Tanaka; Yukihiro Inomata; Seiji Kawasaki; Mitsuo Shimada; Norihiro Kokudo; Hiroto Egawa; Hideki Ohdan; Shinji Uemoto
• Keywords: Adult; Graft Rejection; Male; Adolescent; Incidence; Graft Survival; Middle Aged; Prognosis; Liver Transplantation; 3. Good health; Survival Rate; Young Adult; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Biliary Atresia; Risk Factors; Living Donors; Humans; Female; Registries; Aged; Follow-Up Studies

Biliary atresia (BA) is the most common indication for liver transplantation (LT) in pediatric population. This study analyzed comprehensive factors that might influence outcomes of patients with BA who undergo living donor LT by evaluating largest cohort longest follow-up world. Between November 1989 and December 2015, 2,085 underwent LDLT Japan. There were 763 male 1,322 female recipients a mean age 5.9 years body weight 18.6 kg. The 1-, 5-, 10-, 15-, 20-year graft survival rates undergoing 90.5%, 90.4%, 84.6%, 82.0%, 79.9%, respectively. mass index, ABO incompatibility, type, recipient age, center experience, transplant era found to be significant predictors overall survival. Adolescent (12 <18 years) was associated significantly worse long-term rate than younger or older ages. We conclude safe effective treatment modality does not compromise donors. optimum timing crucial successful outcome, early referral can improve short-term BA. Further investigation major cause death transplanted essential, especially among adolescents