Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections

• DOI: 10.1111/ajt.14546
• Publication Date: 2017-10-25T11:46:38Z
• Authors: Krupa R. Mysore; Rafik M. Ghobrial; Sunil Kannanganat; Laurie J. Minze; Edward A. Graviss; Duc T. Nguyen; Katherine K. Perez; Xian C. Li
• Keywords: Immunosuppression

Current immunosuppression regimens in organ transplantation primarily inhibit T cells. However, cells are also critical protective immunity, especially immune-compromised patients. In this study, we examined the association of cell dysfunction, as marked by expression exhaustion molecules, and posttransplant infections a cohort liver transplant We focused on Programmed Death 1 (PD-1) Ig- mucin-domain molecule 3 (Tim-3), which potent co-inhibitory receptors, their persistent often leads to dysfunction compromised immunity. found that patients with highest PD-1 +Tim-3+ memory compartment before had increased incidence after transplantation, within first 90 days. Longitudinal analysis year showed strong between variability Tim-3 infectious episodes Furthermore, expressed significantly reduced capacity producing interferon (IFN)-γ vitro, IFN-γ production could be partially reversed blocking Tim-3. Interestingly, percentage Foxp3+ regulatory was stable study period. concluded functional status shown expression, may valuable prognosis management infections.