Is COVID-19 infection more severe in kidney transplant recipients?

• DOI: 10.1111/ajt.16424
• Publication Date: 2020-12-01T23:44:38Z
• Authors: Sophie Caillard; Nathalie Chavarot; Hélène Francois; Marie Matignon; Clarisse Greze; Nassim Kamar; Philippe Gatault; Olivier Thaunat; Tristan Legris; Luc Frimat; Pierre F. Westeel; Valentin Goutaudier; Mariam Jdidou; Renaud Snanoudj; Charlotte Colosio; Antoine Sicard; Dominique Bertrand; Christiane Mousson; Jamal Bamoulid; Christophe Masset; Antoine Thierry; Lionel Couzi; Jonathan M. Chemouny; Agnes Duveau; Valerie Moal; Gilles Blancho; Philippe Grimbert; Antoine Durrbach; Bruno Moulin; Dany Anglicheau; Yvon Ruch; Charlotte Kaeuffer; Ilies Benotmane; Morgane Solis; Yannick LeMeur; Marc Hazzan; Francois Danion
• Keywords: Univariate analysis

There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients nontransplant patients. We enrolled two groups patients hospitalized for COVID-19, that is, kidney (KTR) from French Registry Solid Organ Transplant (n = 306) a single-center cohort 795). An analysis was performed among subgroups matched age factors or mortality. Severe defined as admission (or transfer) to an intensive care unit, need mechanical ventilation, death. were younger had more comorbidities They presented with higher creatinine levels developed episodes acute injury. After matching, 30-day cumulative incidence did not differ KTR patients; however, COVID-19-related significantly in (17.9% vs 11.4%, respectively, p .038). Age >60 years, cardiovascular disease, dyspnea, fever, lymphopenia, C-reactive protein (CRP) associated univariate analysis, whereas status serum not. hypertension, diabetes, CRP mg/L, (HR 1.55), level >115 µmol/L 2.32) analysis. In multivariable fever level>115 retained their independent associations