GSTP1is a hub gene for gene-air pollution interactions on childhood asthma

• DOI: 10.1111/all.12298
• Publication Date: 2013-10-14T08:42:53Z
• Authors: M. W. Su; C. H. Tsai; K. Y. Tung; B. F. Hwang; P. H. Liang; B. L. Chiang; Y. H. Yang; Y. L. Lee
• Keywords: GSTP1

There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of pollution on general population, effects childhood asthma can be better understood. We conducted Taiwan Children Health Study (TCHS) to investigate influence gene–air interactions Complete monitoring data for ambient were collected from Environmental Protection Agency stations. Our results show a significant two-way interaction between glutathione S-transferase P (GSTP1) PM10 risk Interactions GSTP1 different types have higher information gain than other pollutant combinations. study suggests most influential model The combined gene may alter susceptibility It implies an important hub in anti-oxidative pathway buffers harmful pollution.