The cat lipocalin Fel d 7 and its cross‐reactivity with the dog lipocalin Can f 1

• DOI: 10.1111/all.12955
• Publication Date: 2016-06-11T14:06:50Z
• Authors: D. Apostolovic; S. Sánchez‐Vidaurre; K. Waden; M. Curin; J. Grundström; G. Gafvelin; T. Cirkovic Velic...; H. Grönlund; W. R. Thomas; R. Valenta; C. Hamsten; M. van Hage
• Keywords: Cross-reactivity

We investigated the prevalence of sensitization to cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity cross-reactivity with dog Can f 1. Sixty-five had IgE rFel whereof 60 also rCan A moderate correlation between levels 1 was found. activated basophils in vitro inhibited binding 4 13 patients, whereas patients. showed high similarities protein structure epitopes common were found using cross-reactive antisera. is a allergen population that cross-reacts 1, may contribute symptoms cat- but dog-allergic