Performance in real life of the European Network on Drug Allergy algorithm in immediate reactions to beta‐lactam antibiotics

• DOI: 10.1111/all.13032
• Publication Date: 2016-08-20T14:42:47Z
• Authors: E. Moreno; E. Laffond; F. Muñoz‐Bellido; M. T. Gracia; E. Macías; A. Moreno; I. Dávila
• Keywords: Drug allergy; Beta-lactam

European Network on Drug Allergy (ENDA) has proposed an algorithm for diagnosing immediate beta-lactam (BL) allergy. We evaluated its performance in real life. During 1994-2014, 1779 patients with suspected reactions to BL were following ENDA's short diagnostic algorithm. Five hundred and nine (28.6%) diagnosed of hypersensitivity. Of them, 457 (25.7%) at first evaluation [403 by skin tests (ST), 12 positive IgE 42 controlled provocation (CPT)]. At second (SE), 52 additional (10.2% allergic patients) diagnosed, [50 (2.8%) ST 2 (0.1%) CPT]. Time between reaction study was significantly longer SE (median 5 vs months; IQR 34 170; P < 0.0001). Anaphylaxis associated a diagnosis SE. Allergy/EAACI protocol appropriate safe when evaluating reactions. Re-evaluation should be performed, particularly anaphylaxis long interval are present.