Changes in patient quality of life during oral immunotherapy for food allergy

• DOI: 10.1111/all.13211
• Publication Date: 2017-05-23T23:28:57Z
• Authors: N. Epstein Rigbi; M. R. Goldberg; M. B. Levy; L. Nachshon; K. Golobov; A. Elizur
• Keywords: Oral immunotherapy; Peanut Allergy; Oral food challenge; Clinical endpoint

Quality of life (QOL) is impaired in patients with food allergy and improves following oral immunotherapy (OIT). However, the treatment itself prolonged demanding. We examined changes patient QOL during OIT for allergy.The FAQLQ-PF was administered to children aged 4-12 years undergoing milk, peanut, or egg allergy, at beginning after 4 months treatment. Patients were categorized as improved, unchanged, diminished (>0.5 point decrease, a change ≤0.5 points, >0.5 increase, respectively) compared. Food-allergic not served controls.The Food Anxiety, Social Dietary Limitation, total scores improved significantly study period (P=.001, P=.018, P=.01, treated but control patients, while Emotional Impact did not. The independent maximal tolerated dose baseline four treatment, pace number severity reactions experienced. score inversely associated on multivariate analysis (regression coefficient=-0.56, P<.001). That driven primarily by improvement high (worse QOL) baseline. Some low (better deteriorated.QOL some deteriorates others OIT. improve despite burden. better might deteriorate