A prospective microbiome‐wide association study of food sensitization and food allergy in early childhood

• DOI: 10.1111/all.13232
• Publication Date: 2017-06-20T18:20:58Z
• Authors: Jessica H. Savage; Kathleen A. Lee‐S...; Joanne Sordillo; Supinda Bunyavanich; Yanjiao Zhou; George O'Connor; Megan Sandel; Leonard B. Bacharier; Robert Zeiger; Erica Sodergren; George M. Weinstock; Diane R. Gold; Scott T. Weiss; Augusto A. Litonjua
• Keywords: Male; 0301 basic medicine; Microbiota; Life Sciences; 610; Biodiversity; Allergens; Immunoglobulin E; Gastrointestinal Microbiome; 3. Good health; 618; 03 medical and health sciences; Child, Preschool; Medicine and Health Sciences; Humans; Metagenome; Female; Immunization; Metagenomics; Food Hypersensitivity

Alterations in the intestinal microbiome are prospectively associated with development of asthma; less is known regarding role alterations food allergy development.Intestinal samples were collected at age 3-6 months children participating follow-up phase an interventional trial high-dose vitamin D given during pregnancy. At 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed. Food defined as caretaker report healthcare provider-diagnosed above prior 3 evidence IgE sensitization. Analysis performed using Phyloseq and DESeq2; P-values adjusted for multiple comparisons.Complete data available 225 children; there 87 cases 14 allergy. Microbial diversity measures did not differ between controls. The genera Haemophilus (log2 fold change -2.15, P=.003), Dialister -2.22, P=.009), Dorea -1.65, P=.02), Clostridium -1.47, P=.002) underrepresented among subjects Citrobacter -3.41, P=.03), Oscillospira -2.80, Lactococcus -3.19, P=.05), -3.00, P=.05) allergy.The temporal association bacterial colonization suggests that may have a causal Our findings therapeutic implications prevention treatment