Quantitative analysis of multiple elements in healthy and remodeled epithelium from human upper airway mucosa using nuclear microscopy

• DOI: 10.1111/all.13329
• Publication Date: 2017-10-11T07:07:10Z
• Authors: M.‐Q. Ren; Y.‐T. Zhou; H.‐X. Chen; T.‐Y. Li; S. K. Vajandar; T. Osipowicz; F. Watt; C.‐W. Li
• Keywords: Respiratory Mucosa

Elements are vital in airway mucosal physiology and pathology, but their distribution levels the mucosa remain unclear. This study uses state-of-the-art nuclear microscopy facility to map quantify multiple elements histology sections of nasal from patients with polyps or inverted papilloma. Our results demonstrate that P Ca most abundant distinct difference between epithelial subepithelial regions; more importantly, our reveal decreased amounts Cu Zn remodeled epithelium as compared normal epithelium. These findings suggest may be beneficial targets regulate aberrant remodeling inflammation.