Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules

• DOI: 10.1111/all.13338
• Publication Date: 2017-10-21T02:34:41Z
• Authors: F. Cipriani; C. Mastrorilli; S. Tripodi; G. Ricci; S. Perna; V. Panetta; R. Asero; A. Dondi; A. Bianchi; N. Maiello; M. Miraglia del G...; T. Frediani; F. Macrì; S. Lucarelli; I. Dello Iacono; M. F. Patria; E. Varin; D. Peroni; L. Chini; V. Moschese; R. Bernardini; G. Pingitore; U. Pelosi; M. Tosca; F. Paravati; I. Sfika; A. Di Rienzo Businco; C. Povesi Dascola; P. Comberiati; S. Frediani; C. Lambiase; M. C. Verga; D. Faggian; M. Plebani; M. Calvani; C. Caffarelli; P. M. Matricardi
• Keywords: Phleum; Atopy

Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities, and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed analyzing the characteristics of IgE sensitization Phleum pratense molecules investigating diagnostic relevance such childhood.We examined 1120 children (age 4-18 years) with SARg. Standardized questionnaires on atopy were acquired through informatics platform (AllergyCARD™). Skin prick tests performed pollen extracts. Serum airborne allergens eight P. (rPhl p 1, rPhl 2, 4, 5b, 6, 7, 11, 12) tested by ImmunoCAP FEIA.The analysis responses against showed 87 profiles. According number recognized IgE, more complex profiles characterized higher serum total grass-specific degree pollens. most frequent profile was monomolecular Phl 1. Sensitization 7 reliable biomarker asthma, whereas 12 oral allergy syndrome. associated severity SARg, longer disease duration.In large pediatric population, complexity related atopic features although useless for predicting clinical severity. detection can be used as biomarkers SARg comorbidities. Further studies different areas are required test impact AIT response.