Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document

• DOI: 10.1111/all.13690
• Publication Date: 2018-12-05T05:58:53Z
• Authors: Ioana Agache; Rachel Miller; James E. Gern; Peter W. Hellings; Marek Jutel; Antonella Muraro; Wanda Phipatanakul; Santiago Quirce; David Peden
• Keywords: Big Data; Proteomics; allergic diseases; 0303 health sciences; biomarkers; PRACTALL; Genomics; asthma; exposome; Risk Assessment; Asthma; United States; 3. Good health; Europe; Exposome; 03 medical and health sciences; Risk Factors; Hypersensitivity; Humans; Genetic Predisposition to Disease; Disease Susceptibility; Precision Medicine; environment; Biomarkers

AbstractExposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to allergic diseases and asthma. Under the PRACTALL collaboration between the European Academy of Allergy and Clinical Immunology (EAACI) and the American Academy of Allergy, Asthma, and Immunology (AAAAI), we evaluated the current concepts and the unmet needs on the role of the exposome in allergic diseases and asthma.