Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

• DOI: 10.1111/all.13740
• Publication Date: 2019-02-11T09:26:09Z
• Authors: Inês Paciência; João Cavaleiro Rufo; Diana Silva; Carla Martins; Francisca Mendes; Mariana Farraia; Luís Delgado; Eduardo de Olivei...; Patrícia Padrão; Pedro Moreira; Milton Severo; Henrique Barros; André Moreira
• Keywords: Male; 0301 basic medicine; Pediatric Obesity; Endocrine Disruptors; Autonomic Nervous System; 03 medical and health sciences; Humans; Child; 2. Zero hunger; Air Pollutants; Volatile Organic Compounds; Health sciences, Medical and Health sciences; Ciências médicas e da saúde; Environmental Exposure; Overweight; Asthma; Respiratory Function Tests; 3. Good health; Air Pollution, Indoor; Population Surveillance; Medical and Health sciences; Female; Ciências da Saúde, Ciências médicas e da saúde; Disease Susceptibility; Symptom Assessment

Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these affect health is poorly known. We aimed assess the association between EDCs exposure and asthma, respiratory symptoms obesity in schoolchildren.Data from a cross-sectional analysis of 815 participants 20 schools Porto, Portugal, were analysed. Symptoms assessed, asthma was defined on lung function, airway reversibility body mass index (BMI) calculated. The concentrations 13 volatile organic compounds 2 aldehydes identified measured 71 classrooms throughout 1 week. Principal component (PCA) used effect co-exposure. Associations estimated by regression coefficients using linear logistic models.Increased individual combined levels found having more children with obesity. Higher hexane, styrene, cyclohexanone, butylated hydroxytoluene 2-butoxyethanol associated obesity, higher cyclohexanone increased child BMI. Toluene, o-xylene, m/p-xylene ethylbenzene significantly nasal obstruction. A positive PC1 risk obese (OR = 1.43, 95% CI 1.01, 1.98) PC2 overweight 1.51, 1.28, 1.79). also obstruction, breathing difficulties lean mass, although low.Our findings further support role development. Moreover, even low indoor influence