Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity
Male
0301 basic medicine
Pediatric Obesity
Endocrine Disruptors
Autonomic Nervous System
03 medical and health sciences
Humans
Child
2. Zero hunger
Air Pollutants
Volatile Organic Compounds
Health sciences, Medical and Health sciences
Ciências médicas e da saúde
Environmental Exposure
Overweight
Asthma
Respiratory Function Tests
3. Good health
Air Pollution, Indoor
Population Surveillance
Medical and Health sciences
Female
Ciências da Saúde, Ciências médicas e da saúde
Disease Susceptibility
Symptom Assessment
DOI:
10.1111/all.13740
Publication Date:
2019-02-11T09:26:09Z
AUTHORS (13)
ABSTRACT
Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these affect health is poorly known. We aimed assess the association between EDCs exposure and asthma, respiratory symptoms obesity in schoolchildren.Data from a cross-sectional analysis of 815 participants 20 schools Porto, Portugal, were analysed. Symptoms assessed, asthma was defined on lung function, airway reversibility body mass index (BMI) calculated. The concentrations 13 volatile organic compounds 2 aldehydes identified measured 71 classrooms throughout 1 week. Principal component (PCA) used effect co-exposure. Associations estimated by regression coefficients using linear logistic models.Increased individual combined levels found having more children with obesity. Higher hexane, styrene, cyclohexanone, butylated hydroxytoluene 2-butoxyethanol associated obesity, higher cyclohexanone increased child BMI. Toluene, o-xylene, m/p-xylene ethylbenzene significantly nasal obstruction. A positive PC1 risk obese (OR = 1.43, 95% CI 1.01, 1.98) PC2 overweight 1.51, 1.28, 1.79). also obstruction, breathing difficulties lean mass, although low.Our findings further support role development. Moreover, even low indoor influence
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