Quality of life of children aged 8‐12 years undergoing food allergy oral immunotherapy: Child and parent perspective

• DOI: 10.1111/all.14350
• Publication Date: 2020-04-30T02:57:00Z
• Authors: Na'ama Epstein‐Rigbi; Michael R. Goldberg; Michael B. Levy; Liat Nachshon; Arnon Elizur
• Keywords: Parents; 2. Zero hunger; Administration, Oral; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Desensitization, Immunologic; Surveys and Questionnaires; Quality of Life; Humans; Immunotherapy; Child; Food Hypersensitivity

AbstractBackgroundOral immunotherapy (OIT) for food allergy improves the quality of life (QOL) of children from parental perspective but little is known about the child perception.MethodsThe Food Allergy Quality of Life Questionnaire—Child Form (FAQLQ‐CF) was administered to children aged 8‐12 years, and the FAQLQ—Parent Form (FAQLQ‐PF) was administered to their parents at the start of OIT for milk, egg, peanut, sesame, or tree nuts, at the end of up‐dosing, and after 6 months of follow‐up. Food‐allergic children not undergoing OIT served as controls. Children QOL scores were compared to their parents.ResultsThe total FAQLQ‐CF score of 103 children undergoing OIT improved significantly from start of OIT (median (IQR); 4.8, 3.8‐5.7) to end of up‐dosing (3.9, 3‐5.2) (P < .001). A greater improvement was noted in the 56 children who reached a follow‐up visit, from 5.0 (3.7‐5.8) at OIT start to 3.1 (1.8‐5.0) on follow‐up, (P < .001). In contrast, FAQLQ‐CF scores of control patients improved mildly and nonsignificantly between the two time points from 5.3 (4.3‐5.7) to 4.8 (3.6‐6.0), (P = .13). The improvement in the total FAQLQ‐CF scores from OIT start to follow‐up was significantly greater compared to the change in control patients during observation (P = .015). Parents reported better QOL scores compared to their children at all stages of OIT (start 4.0, 3.2‐5, P = .004; end of up‐dosing 2.9, 1.9‐4.7, P = .04; follow‐up 2.2, 1.6‐3.6, P = .003).ConclusionsQOL of food‐allergic children undergoing OIT improves significantly compared to controls. Parents perceive QOL to be better than the perception of the children.