Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis

• DOI: 10.1111/all.14842
• Publication Date: 2021-04-08T14:15:45Z
• Authors: Arturo O. Rinaldi; Angelica Korsfeldt; Siobhan Ward; Daniel Burla; Anita Dreher; Marja Gautschi; Britta Stolpe; Ge Tan; Eugen Bersuch; David Melin; Nima Askary Lord; Simon Grant; Per Svedenhag; Kristina Tsekova; Peter Schmid‐Gren...; Matthias Möhrensc...; Ellen D. Renner; Cezmi A. Akdis
• Keywords: Transepidermal water loss; Dry skin; SCORAD; Skin Barrier

Allergic disorders such as atopic dermatitis (AD) are strongly associated with an impairment of the epithelial barrier, in which tight junctions and/or filaggrin expression can be defective. Skin barrier assessment shows potential to clinically useful for prediction disease development, improved and earlier diagnosis, lesion follow-up, therapy evaluation. This study aimed establish a method directly assess vivo status using electrical impedance spectroscopy (EIS).Thirty-six patients AD were followed during their 3-week hospitalization compared 28 controls. EIS transepidermal water loss (TEWL) measured lesional non-lesional skin. Targeted proteomics by proximity extension assay serum whole-genome sequence performed.Electrical was able integrity, differentiate between controls without AD, characterize skin patients. It showed significant negative correlation TEWL, but higher sensitivity discriminate from During hospitalization, lesions reported increase that correlated healing, decreased SCORAD itch scores. Additionally, inverse biomarkers inflammatory pathways may affect particularly chemokines CCL13, CCL3, CCL7, CXCL8 other cytokines, IRAK1, IRAK4, FG2, significantly high at admission. Furthermore, copy numbers on patients.Electrical tool detect dysfunction vivo, valuable severity, progression, efficacy.