The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update

• DOI: 10.1111/all.15214
• Publication Date: 2022-01-10T15:19:48Z
• Authors: Marcus Maurer; Markus Magerl; Stephen Betschel; Werner Aberer; Ignacio J. Ansotegui; Emel Aygören‐Pürsün; Aleena Banerji; Noémi‐Anna Bara; Isabelle Boccon‐G...; Konrad Bork; Laurence Bouillet; Henrik Balle Boysen; Nicholas Brodszki; Paula J. Busse; Anette Bygum; Teresa Caballero; Mauro Cancian; Anthony Castaldo; Danny M. Cohn; Dorottya Csuka; Henriette Farkas; Mark Gompels; Richard Gower; Anete S. Grumach; Guillermo Guidos‐...; Michihiro Hide; Hye‐Ryun Kang; Allen Phillip Kaplan; Constance Katelaris; Sorena Kiani‐Alikhan; Wei‐Te Lei; Richard Lockey; Hilary Longhurst; William R. Lumry; Andrew MacGinnitie; Alejandro Malbran; Inmaculada Martin...; Juan José Matta; Alexander Nast; Dinh Nguyen; Sandra A. Nieto‐M...; Ruby Pawankar; Jonathan Peter; Grzegorz Porebski; Nieves Prior; Avner Reshef; Marc Riedl; Bruce Ritchie; Farrukh Rafique S...; William B. Smith; Peter J. Spaeth; Marcin Stobiecki; Elias Toubi; Lilian Agnes Varga; Karsten Weller; Andrea Zanichelli; Yuxiang Zhi; Bruce Zuraw; Timothy Craig
• Keywords: Guideline; Hereditary Angioedema; Delphi Method; C1-inhibitor; Delphi

Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis effective therapy are critical. This revision update of the global WAO/EAACI guideline on management HAE provides up-to-date guidance HAE. For this guideline, an international panel experts reviewed existing evidence, developed 28 recommendations, established consensus by online DELPHI process. The goal these recommendations to help physicians their patients in making rational decisions with deficient C1 inhibitor (type 1) dysfunctional 2), providing common important clinical issues, such as: (1) How should be diagnosed? (2) When receive prophylactic top on-demand treatment what treatments used? (3) What goals treatment? (4) Should different special patient groups as children or pregnant/breast-feeding women? (5) monitor activity, impact, control? It also intention establish standards encourage facilitate use recommended diagnostics therapies all patients.